Milford is a city in Clermont and Hamilton counties in the U.S. state of Ohio. Milford is the westernmost city in Appalachian Ohio, and locateā¦Milford is a city in Clermont and Hamilton counties in the U.S. state of Ohio. Milford is the westernmost city in Appalachian Ohio, and located along the Little Miami River and its East Fork in the southwestern part of the state, it is a part of the Cincinnati metropolitan area. The population was 6,582 at the 2020 census.