San Francisco 49ers face a daunting Week 17 test against Detroit Lions with injuries threatening their ability to compete.

For Lions defensive coordinator Aaron Glenn's money, 49ers star George Kittle is the best tight end in football.

#Lions HC Dan Campbell says last year's 49ers loss still hurts. He likened it to his Super ... Dharya Sharma is an ...

San Francisco 49ers tight end George Kittle has recorded three games with at least 100 receiving yards this season, the most ...

San Francisco 49ers top scorers look to capitalize on opportunities early against Detroit Lions stout defense.

A California appeals court has overturned the rape conviction of former San Francisco 49er Dana Stubblefield after ...

All three Saturday games on the Week 17 NFL schedule will have a significant impact on the NFL postseason. The Los Angeles ...

Less than a year ago, the 49ers and the Lions were the two best teams in the NFC. Now the Lions are on the verge of locking up the no. 1 seed.

The Detroit Lions and San Francisco 49ers met 11 months ago at Levi's Stadium with a trip to the Super Bowl on the line. San Francisco used a furious second half comeback to steal the NFC Championship ...

Nick Bosa and a San Francisco 49ers teammate spoke about playing for "Integrity" after NFL playoff elimination.

Here are the lines, spreads and totals for all 16 games on the Week 17 slate. Football Power Index (FPI) by ESPN Analytics.

Two more weeks of football remain, and we’ll know where the San Francisco 49ers’ draft position in the 2025 NFL draft is.